J Bone Joint Infect 2017; 2(1):23-28. doi:10.7150/jbji.16649

Review

Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery

Andrew N. Fleischman, Matthew S. Austin

Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA, United States.

Abstract

Surgical site infection (SSI) is one of the most common complications after orthopaedic surgery, leading to significant morbidity and its associated costs. Surgical guidelines strongly recommend the use of systemic antibiotic prophylaxis to reduce the risk for developing SSI. Locally administered powdered antibiotics have the potential to provide remarkably high intra-wound concentrations without risk for systemic toxicity. However, a paucity of high quality evidence in the orthopaedic literature has prevented widespread adoption of this technique. The majority of clinical studies on local intra-wound antibiotics have evaluated the use of topical powdered vancomycin in spinal surgery, though only a single prospective study currently exists. This review will discuss all the available evidence describing the effectiveness, pharmacokinetics, and potential adverse effects with the use of topical powdered antibiotics in orthopedic surgery.

Keywords: Surgical site infection, orthopaedic surgery

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How to cite this article:
Fleischman AN, Austin MS. Local Intra-wound Administration of Powdered Antibiotics in Orthopaedic Surgery. J Bone Joint Infect 2017; 2(1):23-28. doi:10.7150/jbji.16649. Available from http://www.jbji.net/v02p0023.htm