J Bone Joint Infect 2017; 2(2):84-89. doi:10.7150/jbji.17507

Research Paper

Bone Inflammation, Bone Infection and Dental Implants Failure: Histological and Cytological Aspects Related to Cement Excess

Marco Tatullo1✉, Massimo Marrelli2, Filiberto Mastrangelo3, Enrico Gherlone3

1. Biomedical Section, Tecnologica Research Institute, Crotone, Italy.
2. Maxillofacial Unit, Calabrodental clinic, Crotone, Italy.
3. Department of Oral Science, “Vita e Salute” San Raffaele University, Milan, Italy.


Background: Dental implant failure can recognize several causes and many of them are quite preventable with the right knowledge of some clinical critical factors. Aim of this paper is to investigate about the histological aspects related to dental implants failure in such cases related to cement excess, how such histological picture can increase the risk of bacterial infections and how the different type of cement can interact with osteoblasts in-vitro.

Methods: We randomly selected 5 patients with a diagnosis of dental implant failure requiring to be surgically removed: in all patients was observed an excess of dental cement around the failed implants. Histological investigations were performed of the perimplant bone. Cell culture of purchased human Osteoblasts was performed in order to evaluate cell proliferation and cell morphology at 3 time points among 3 cement types and a control surface.

Results: Dental cement has been related to a pathognomonic histological picture with a foreign body reaction and many areas with black particles inside macrophage cells. Finally, cell culture on different dental cements resulted in a lower osteoblasts survival rate.

Conclusions: It is appropriate that the dentist puts a small amount of dental cement in the prosthetic crown, so to avoid the clinical alterations related to the excess of cement.

Keywords: implant failure, osteoblasts, osseointegration.

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How to cite this article:
Tatullo M, Marrelli M, Mastrangelo F, Gherlone E. Bone Inflammation, Bone Infection and Dental Implants Failure: Histological and Cytological Aspects Related to Cement Excess. J Bone Joint Infect 2017; 2(2):84-89. doi:10.7150/jbji.17507. Available from http://www.jbji.net/v02p0084.htm