J Bone Jt Infect 2018; 3(1):10-14. doi:10.7150/jbji.21567

Research Paper

Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals

Emeli Månsson1,2,4✉, Berolla Sahdo2, Åsa Nilsdotter-Augustinsson5, Eva Särndahl1,2, Bo Söderquist1,3

1. School of Medical Sciences,
2. iRiSC - Inflammatory Response and Infection Susceptibility Centre,
3. Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden;
4. Region Västmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland Västerås, SE-721 89 Västerås, Sweden;
5. Department of Infectious Diseases, and Department of Clinical and Experimental Medicine, Linköping University, SE-60182 Norrköping, Sweden.

Abstract

Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.

Keywords: Staphylococcus epidermidis, prosthetic joint infections, host-pathogen interaction, caspase-1, neutrophils

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How to cite this article:
Månsson E, Sahdo B, Nilsdotter-Augustinsson Å, Särndahl E, Söderquist B. Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals. J Bone Jt Infect 2018; 3(1):10-14. doi:10.7150/jbji.21567. Available from http://www.jbji.net/v03p0010.htm