J Bone Jt Infect 2018; 3(5):255-257. doi:10.7150/jbji.30029

Short Communication

Rifampin-Resistant Cutibacterium (formerly Propionibacterium) namnetense Superinfection after Staphylococcus aureus Bone Infection Treatment

Stéphane Corvec1,2,3✉, Aurélie Guillouzouic1, Guillaume Ghislain Aubin1, Sophie Touchais3,4, Olivier Grossi3,5, François Gouin3,4, Pascale Bémer1,3

1. Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France
2. CRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France
3. Nantes study group member of CRIOGO (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest), Nantes, France
4. Clinique chirurgicale orthopédique et traumatique, CHU de Nantes, Nantes, France.
5. Service de Maladies infectieuses, CHU de Nantes, Nantes, France - Département de Médecine Interne -Infectiologie, Nouvelles Cliniques Nantaises, Nantes, France

Abstract

After rifampin and levofloxacin treatment for a Staphylococcus aureus bone infection, a pyogenic granuloma due to a newly described Cutibacterium species, C. namnetense developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the rpoB gene. This case illustrates the possible in vivo selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment.

Keywords: bone infection, rifampin, Cutibacterium namnetense, Staphylococcus aureus, resistance

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How to cite this article:
Corvec S, Guillouzouic A, Aubin GG, Touchais S, Grossi O, Gouin F, Bémer P. Rifampin-Resistant Cutibacterium (formerly Propionibacterium) namnetense Superinfection after Staphylococcus aureus Bone Infection Treatment. J Bone Jt Infect 2018; 3(5):255-257. doi:10.7150/jbji.30029. Available from http://www.jbji.net/v03p0255.htm