J Bone Jt Infect 2019; 4(1):50-55. doi:10.7150/jbji.30615

Case Report

Metagenomic next-generation sequencing contribution in identifying prosthetic joint infection due to Parvimonas micra: a case report

Zida Huang1*, Chongjing Zhang1*, Wenbo Li1, Xinyu Fang1, Qijin Wang1, Li Xing3, Yingzhen Li3, Xifang Nie3, Bin Yang2, Wenming Zhang1✉

1. Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China
2. Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China
3. BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China
* Both authors contributed equally to this work.

Abstract

Identifying fastidious pathogens in patients with prosthetic joint infection (PJI) by culture is challenging. Metagenomic next-generation sequencing (mNGS) is a novel culture-independent approach that is associated with a higher likelihood for identifying pathogens. We present a case where mNGS was implemented to identify Parvimonas micra, a rarely reported and difficult-to-culture PJI pathogen.

Keywords: Prosthetic joint infection, Parvimonas micra, Metagenomic next-generation sequencing

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How to cite this article:
Huang Z, Zhang C, Li W, Fang X, Wang Q, Xing L, Li Y, Nie X, Yang B, Zhang W. Metagenomic next-generation sequencing contribution in identifying prosthetic joint infection due to Parvimonas micra: a case report. J Bone Jt Infect 2019; 4(1):50-55. doi:10.7150/jbji.30615. Available from http://www.jbji.net/v04p0050.htm