J Bone Jt Infect 2019; 4(6):280-284. doi:10.7150/jbji.35424

Research Paper

Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro

Stylianaki Aikaterini1, Stanic Barbara1, Morgenstern Mario2, Richards R. Geoff1, Moriarty T. Fintan1✉, Thompson Keith1

1. AO Research Institute Davos, Davos, Switzerland.
2. Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland.

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Citation:
Aikaterini S, Barbara S, Mario M, Geoff RR, Fintan MT, Keith T. Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro. J Bone Jt Infect 2019; 4(6):280-284. doi:10.7150/jbji.35424. Available from http://www.jbji.net/v04p0280.htm

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Abstract

Polytrauma is associated with increased risk of sepsis, but the risk for implant infection is less clear. Neutrophil antibacterial responses are significantly reduced in polytrauma patients (n= 9, ISS≥15) for at least 5 days compared to healthy controls. Reduced neutrophil activity could influence implant infection in addition to sepsis.

Keywords: polytrauma, neutrophil, antibacterial activity